Novel science and novel applications of science constantly give us new technologies and change how, when and where we live our lives, and even how long those lives will be.

Mostly, those changes are for the better.

But not all technology is benign or applied to benign ends.
How should we respond?

And, as Machiavelli pointed out five hundred years ago, change creates winners and losers.

Who wins, who loses and how will the losers respond?